Non-LSD Ergoloids

The research chemical market is based on the philosophy of tweaking existing recreational molecular backbones, yet compounds based on LSD appear to be few and far between. There is nothing at all preventing the existence of exotic research chemicals based on the ergoloid backbone, and in fact several are known that have significant recreational potential based on academic studies. The interesting fact is that none of them appear to have hit the market in significant volume. Perhaps this is simply the result of watched precursors and more elaborate synthesis routes than established products, but experimentation by the research chemical market seems rather lackluster based on the reputation of the parent drug and possible potential.

There are some who argue that experimentation of this nature has been ongoing, but has been executed through entirely different distribution channels – namely the LSD black market. Certain blotter prints have been distributed with something that could pass for LSD but seems different to experienced tastes. This particular variant has been described as a sort of neo-LSD that appears more euphoric, more visual, shorter acting, and less “spiritual” with the accompanying decrease in potential for anxiety.

One suspected blotter print is the 1906-2008 Hoffman Oms. This is not a esoteric print with limited circulation. It celebrates the life of Albert Hofmann, who lived from 1906 to 2008 and was the first to synthesize and consume LSD. It is part of a larger recurring blotter art series that is consistently widely distributed and well received, and as such appears to originate from the depths of the notoriously secretive LSD black market.

Sufficient suspicions were raised about the contents of this blotter to instigate a GC/MS test.

Initial evaluation seemed to bear out the hypothesis that these results reflected a novel and interesting compound closely related to LSD, perhaps lysergic acid 2-butyl amide (LSB) or lysergic acid 3-pentyl amide (LSP). These early interpretations of the GC/MS results were challenged however.

sec-LSB gives an almost indistinguishable MS to actual LSD, so I doubt it’s that. It’s not the N-(3-Pentyl) derivative [..] as well[.]

I personally have not a clue what this is — the fragment for d-Lysergic acid diethylamide, LAMPA or sec-LSB is always at 324, yet here we have 326 (the only one that comes to mind is deuterated-LSD which is usually 327). The huge peak at 72 is suspicious and the initial peaks at 44/58 as well (small substituted amines?).

296-208 is usual fragment for N-Et-LSD and a peak adjacent to 209 is present
310-209 characteristic of nor-LSD/nor-iso-LSD

So, you’re missing quite a bunch of the normal peaks but you have what might be degradation products or side impure product present, but it seems pretty inconclusive.

-nuke

Unfortunately it appears that no clear conclusions can be drawn. The blotter cannot be positively identified as LSD, but it also cannot be identified as a closely related compound or even as a completely different psychedelic compound. These blotters were clearly active in man, and displayed a psychedelic character very close to LSD. The major issue is lack of comprehensive test results, as GC/MS analysis is not easily available. Even if these tests are conducted, the data is not typically shared widely. It seems likely that these problems will become more manageable as technology progresses.

It is very likely that closely related compounds to LSD have been synthesized and tested in man. The precursors are available, the skills are out there, and the desire exists. Whether these exotic relatives of the world’s most famous psychedelic remain limited to a select few or have been surreptitiously released on a wider scale to a mostly unaware public remains to be seen.

Bluelight Forum > Focus Forums > Psychedelic Drugs > The Big & Dandy Non-LSD Ergoloids Blotter Thread.

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    • shakalaka
    • December 2nd, 2011

    This is a great post. I do wonder why someone would go out of there way to produce these analogues? I assume the precursors are still controlled and the synth would be just as difficult as LSD (assumptions) so why bother?

    • When George Mallory was asked why he wanted to climb Everest, he replied “Because it’s there.” A similar desire for exploration may apply to the very few chemists possessing the skill and access to the required precursors. There are also practical considerations – certain analogs could be more potent leading to more profit, or possess varying effects that could appeal to different markets.

      There were other novel substances as well. Leonard [Pickard] made a new LSD analog called “diazedine,” though I don’t know exactly what that was either.

      Are you familiar with lysergic acid 2,4-dimethylazetidide?*

      No, but they were calling this diazedine. It was also crazy, but nothing earth-shattering. Leonard [Pickard] gave it to Todd [Skinner] in a bottle of Everclear for testing, and we would dose a capful at a time. Apparently, diazedine failed to be doable on a large scale because the production costs were too high and the yields too low. Diazedine caused a lot of stress between Todd and Leonard, because they had high expectations for it as an LSD alternative.

      *Lysergic acid 2,4-dimethylazetidide (aka LSZ) belongs to a very small group of serotonergic psychedelics that surpass LSD in potency. Aside from the fact that “diazedine” is a lexical clipping of dimethylazetidine (diazedine<dimethylazetidine), the first paper describing the chemistry and pharmacology of LSZ came out of a laboratory at Purdue University, where Leonard had previously studied under the renowned chemist David Nichols. Though the paper was published after Leonard’s arrest, it is still quite likely he was aware of the preliminary research. When I asked Dr. Nichols whether he thought Pickard may have produced LSZ, he replied, “Leonard knew of our work, of that I am certain.” Rumors of LSZ distributed on blotter paper (purportedly under the name λ) have circulated for years, though there are few confirmed reports of its existence. Of course, the name diazedine is ambiguous and could be referring to just about anything, but I would bet a kilo of benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate that LSZ and diazedine are one and the same.

      From an interview of Krystal Cole, Life is a Cosmic Giggle on the Breath of the Universe, Vice Magazine.

      • James
      • December 7th, 2011

      There are some rather obscure uncontrolled precursors out there that may more easily be synthesized to a LSD analog rather than LSD itself. My personal guess as to why more analogs aren’t being synthesized is because people involved with the production of LSD tend to have a belief that it is a special molecule with the ability to change the way people think and how the world operates.

    • Jimmy
    • December 2nd, 2011

    Please post your articles to your twitter feed, at least once, they’re really interesting and I don’t like missing them!

    • Jorge
    • December 9th, 2011

    I already tried this type of bitter blotters and have to agree that this is not LSD but neither is DOB. Nevertheless the experience was good but i would still prefer real L

  1. There is some very interesting research going on with LSx chemicals over at http://herbs.maxforum.org/ , I highly recommend reading the hell out of this site. I at one point backed the entire thing up to my hard drive, and I might have to do it again…

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